研究揭示软珊瑚Xenia中内共生细胞类型的谱系动态

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研究揭示软珊瑚Xenia中内共生细胞类型的谱系动态

2020-08-06 17:46

本期文章:《自然》:Online/在线发表

美国卡内基科学研究所郑诣先、Chen-Ming Fan、Minjie Hu等研究人员合作揭示软珊瑚Xenia中内共生细胞类型的谱系动态。该研究于2020年6月17日在线发表于国际一流学术期刊《自然》。

研究人员报道了一种快速生长的软珊瑚Xenia的染色体水平基因组装配,并使用该物种作为研究珊瑚与藻类共生的模型。单细胞RNA测序鉴定了Xenia中的16个细胞簇,包括胃真皮细胞和刺细胞。研究人员确定了共生细胞类型,其表达一组独特的基因,这些基因与识别、吞噬和/或内吞作用、藻类的维持以及宿主珊瑚细胞的免疫调节有关。通过联合Xenia再生和单细胞RNA测序,研究人员观察到了内共生细胞的动态谱系进程。这些与内共生相关的保守基因可能有助于揭示不同珊瑚吸收或丧失其内共生体的共同原理。

 

据悉,许多珊瑚含有共生的鞭毛藻。这种藻类生活在珊瑚细胞内一个专门的膜区室中,也被称为共生体,其与珊瑚宿主细胞共享光合固定的碳,而宿主细胞为藻类提供无机碳以进行光合作用。这种对维持珊瑚礁生态系统至关重要的内共生,正日益受到环境压力的威胁,导致珊瑚褪色(即内共生的破坏),进而导致珊瑚死亡和海洋生态系统退化。在珊瑚细胞中协调识别、摄取和维持藻类的分子途径仍知之甚少。

 

附:英文原文

Title: Lineage dynamics of the endosymbiotic cell type in the soft coral Xenia

Author: Minjie Hu, Xiaobin Zheng, Chen-Ming Fan, Yixian Zheng

Issue&Volume: 2020-06-17

Abstract: Many corals harbour symbiotic dinoflagellate algae. The algae live inside coral cells in a specialized membrane compartment known as the symbiosome, which shares the photosynthetically fixed carbon with coral host cells while host cells provide inorganic carbon to the algae for photosynthesis1. This endosymbiosis—which is critical for the maintenance of coral reef ecosystems—is increasingly threatened by environmental stressors that lead to coral bleaching (that is, the disruption of endosymbiosis), which in turn leads to coral death and the degradation of marine ecosystems2. The molecular pathways that orchestrate the recognition, uptake and maintenance of algae in coral cells remain poorly understood. Here we report the chromosome-level genome assembly of a Xenia species of fast-growing soft coral3, and use this species as a model to investigate coral–alga endosymbiosis. Single-cell RNA sequencing identified 16 cell clusters, including gastrodermal cells and cnidocytes, in Xenia sp. We identified the endosymbiotic cell type, which expresses a distinct set of genes that are implicated in the recognition, phagocytosis and/or endocytosis, and maintenance of algae, as well as in the immune modulation of host coral cells. By coupling Xenia sp. regeneration and single-cell RNA sequencing, we observed a dynamic lineage progression of the endosymbiotic cells. The conserved genes associated with endosymbiosis that are reported here may help to reveal common principles by which different corals take up or lose their endosymbionts.

DOI: 10.1038/s41586-020-2385-7

Source: https://www.nature.com/articles/s41586-020-2385-7

期刊信息

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
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